Evaluation of the Extracts From Rhizomes of Polygonum bistorta for the Median Lethal Dosages in Swiss Albino Mice

Background: Polygonum bistorta has been used as a remedy for jaundice, smallpox, pimples, measles, cholera, diarrhoea, dysentery, expelling worms, insect stings and snakebites. In this study, the crude extract from P. two fractions viz. hexane chloroform obtained were studied their median Lethal Dosages (LD50) in Swiss albino mice. Methods: Powdered rhizomes of was macerated with dissolved solvent mixture methanol/water (95:5). The then subjected to solvent-solvent partition, first followed by chloroform. evaluated LD50 mice both sexes. Results: determined be 142.82, 200 200.17mg per kg body weight, respectively. Conclusion: values determined. had greater lethality than fractions. This is report on bistorta.